Computational modeling demonstrates that extracellular potentials are highly sensitive to lateral displacement of the excitation wave but insensitive to wavefront length greater than 1 mm.
Requires submillimeter electrode precision for reliable extracellular recordings; extends bidomain modeling of cardiac wavefronts.
Extracellular potentials were calculated for a wave of activation propagating through a thin layer of tissue. Sources were represented on the basis of the bidomain model, with the observation point at the tissue surface. Calculated potentials were found to be insensitive to the length of the wavefront if it passed under the recording electrode provided its length exceeded 1 mm, but to decrease rapidly when the wave passed to a side of the electrode. Contributions of source regions with a lateral displacement from the electrode greater than about 0.3 mm were substantially diminished. The effects of the thickness of the layer and velocity of propagation on amplitude was investigated.
No takes yet. Share an insight, caveat, or question.
Geselowitz et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: