What question did this study set out to answer?

Summarize structural principles and folding pathways governing how proteins organize from local secondary structures into autonomous domains, subunits, and multimeric assemblies.

April 2, 1991Biochemistry

Protein folding: local structures, domains, subunits, and assemblies

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Authors

RJRainer JaenickeUniversity of Regensburg

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Implication

Review reveals hierarchical pathways of protein folding across structural levels, highlighting principles that drive domain organization and macromolecular assembly.

Key Points

Summarize structural principles and folding pathways governing how proteins organize from local secondary structures into autonomous domains, subunits, and multimeric assemblies.
Synthesized biochemical, biophysical, and thermodynamic findings on protein folding, domain stability, and subunit association.
Characterizes protein folding as a hierarchical process where early local secondary structures coalesce into autonomous folding domains.
Demonstrates that quaternary structure formation depends on specific intermediate conformational states during subunit docking and assembly.

Cite This Study

Rainer Jaenicke (1991) studied this question.

synapsesocial.com/papers/6a1bdbdd26cb5670aa9d02e1 https://doi.org/10.1021/bi00227a001

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Implication

Review reveals hierarchical pathways of protein folding across structural levels, highlighting principles that drive domain organization and macromolecular assembly.

Protein folding: local structures, domains, subunits, and assemblies

Discussion

Member takes

Implication

Key Points

Cite This Study

Protein folding: local structures, domains, subunits, and assemblies

Discussion

Member takes

Implication

Key Points

Cite This Study

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