What does this research mean for the field?

Neurologic complications occur in 25% of infective endocarditis episodes, are often present before antimicrobial therapy is initiated, significantly increase acute mortality, and are strongly associated with Staphylococcus aureus infection and multivalvular involvement. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

October 9, 2000Archives of Internal Medicine

Neurologic Manifestations of Infective Endocarditis

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Why the study?

What are the risk factors and outcomes associated with neurologic complications in patients with infective endocarditis?

Population

218 episodes designated as definite or possible infective endocarditis according to Duke criteria treated…

Design

Cohort

Follow-up

Acute phase of IE

Authors

MHMaija HeiroVaasa Central Hospital JNJukka NikoskelainenUniversity of Turku EEErik EngblomUniversity of Turku

Discussion

Member takes

Implication

Warrants vigilance for neurologic complications in S. aureus infective endocarditis; supports consensus on rapid antimicrobial therapy.

Structured PICO

What are the risk factors and outcomes associated with neurologic complications in patients with infective endocarditis?

Population

218 episodes designated as definite or possible infective endocarditis (IE) according to Duke criteria treated during the years 1980 through 1996 in a Finnish teaching hospital

Comparator

Patients with IE who did not have neurologic symptoms

Outcome

Neurologic manifestations and acute phase mortalityhard clinical

Neurologic complications in infective endocarditis are common (25%), often present before antimicrobial therapy, and are associated with S. aureus infection, bi-valvular involvement, and increased mortality.

Cite This Study

Heiro et al. (2000) studied this question.

synapsesocial.com/papers/6a1be08201af05bf0da8f979 https://doi.org/10.1001/archinte.160.18.2781

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Neurologic Manifestations of Infective Endocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neurologic Manifestations of Infective Endocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider