What does this research mean for the field?

Muscle sympathetic nerve activity (MSNA) demonstrates greater short- and medium-term reproducibility and higher sensitivity to changes in sympathetic cardiovascular drive compared to plasma noradrenaline. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1997Clinical Science

Comparison between Reproducibility and Sensitivity of Muscle Sympathetic Nerve Traffic and Plasma Noradrenaline in Man

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Why the study?

Does muscle sympathetic nerve activity offer better reproducibility and sensitivity compared to plasma noradrenaline for assessing sympathetic tone in humans?

Structured PICO

Does muscle sympathetic nerve activity offer better reproducibility and sensitivity compared to plasma noradrenaline for assessing sympathetic tone in humans?

Population

66 subjects total: 10 for reproducibility assessment, 18 across three age groups (young, middle-age, old), 30 across three blood pressure groups (normotensive, mild, severe hypertensive), and 8 before and after a physical training program.

Intervention

Measurement of muscle sympathetic nerve activity (MSNA) by microneurography from a peroneal nerve

Comparator

Measurement of plasma noradrenaline by HPLC from an antecubital vein

Outcome

Reproducibility (correlation across 3 sessions: baseline, 60 min, 14 days) and sensitivity to conditions altering sympathetic drive (aging, hypertension, physical training)surrogate

Muscle sympathetic nerve activity measured by microneurography provides a more reproducible and sensitive index of sympathetic cardiovascular drive than plasma noradrenaline.

Discussion

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Implication

MSNA may offer superior reproducibility for sympathetic assessment; supports preferential research use but leaves clinical replacement of noradrenaline open.

Cite This Study

Grassı et al. (1997) studied this question.

synapsesocial.com/papers/6a1be135ea84844e355f1c10 https://doi.org/10.1042/cs0920285

Topics

Hypertension management

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Implication

MSNA may offer superior reproducibility for sympathetic assessment; supports preferential research use but leaves clinical replacement of noradrenaline open.

Comparison between Reproducibility and Sensitivity of Muscle Sympathetic Nerve Traffic and Plasma Noradrenaline in Man

Structured PICO

Discussion

Implication

Cite This Study

Topics

Comparison between Reproducibility and Sensitivity of Muscle Sympathetic Nerve Traffic and Plasma Noradrenaline in Man

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider