The biochemical aspects of manic-depressive psychosis have been adequately, reviewed by McFarland and Goldstein (1939). From previous investigations, it is apparent that there is a marked alteration in carbohydrate metabolism mainly associated with a change in glucose tolerance. This phenomenon is related to alterations in emotional state and there is no suggestion that it is the cause of the mood swings which occur periodically in this type of psychosis. Apart from these variations in the control of carbohydrate metabolism, it has so far not been possible to demonstrate any changes in the blood levels of any products derived from carbohydrate metabolism.
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Dawson et al. (1954) studied this question.
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