What does this research mean for the field?

A newly developed radioimmunoassay utilizing rabbit antisera and pure human erythropoietin can detect 2-3 mU of erythropoietin in 0.1-0.3 ml volumes, enabling the measurement of normal, subnormal, and elevated serum titers. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1979BloodOpen Access

A radioimmunoassay for erythropoietin

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Population

Rabbits used to raise antisera, and human erythropoietin preparations

Design

Preclinical

Authors

JSJB SherwoodAlbert Einstein College of Medicine EGEUGENE GOLDWASSERUniversity of Chicago

Discussion

Member takes

Implication

May aid preclinical EPO research; leaves open human clinical translation.

Structured PICO

Population

Rabbits used to raise antisera, and human erythropoietin preparations

Intervention

Development of a radioimmunoassay (RIA) for erythropoietin

Outcome

Detection limit and characteristics of the RIA for erythropoietinsurrogate

The development of this radioimmunoassay provides a sensitive method for detecting normal, subnormal, and elevated serum titers of erythropoietin.

Limitations

Does not distinguish between the native (active in vivo) and the asialo form (inactive in vivo)
Cannot yet be used for routine monitoring of crude fractions during purification

Cite This Study

Sherwood et al. (1979) studied this question.

synapsesocial.com/papers/6a1be1895b8f4ede65a930f2 https://doi.org/10.1182/blood.v54.4.885.bloodjournal544885

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A radioimmunoassay for erythropoietin

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

A radioimmunoassay for erythropoietin

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider