What question did this study set out to answer?

Investigate the presence of Chlamydia pneumoniae, Chlamydia trachomatis, and local cytokine expression in cardiovascular tissues from patients undergoing cardiac surgery.

April 1, 2017Infection and Drug ResistanceOpen Access

In situ detection of Chlamydia pneumoniae,C. trachomatis,and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

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Authors

LFLarissa Silva de FreitasUniversidade Federal do Pará NANúbia Caroline Costa de AlmeidaUniversidade do Estado do Pará MQMaria Alice Freitas QueirozUniversidade Federal do Pará

Discussion

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Implication

Observational biopsy study detects Chlamydia antigens and elevated TNF-α in cardiovascular tissues, suggesting persistent infection may contribute to vascular inflammation.

Key Points

Investigate the presence of Chlamydia pneumoniae, Chlamydia trachomatis, and local cytokine expression in cardiovascular tissues from patients undergoing cardiac surgery.
Analyzed 69 tissue biopsies (16 atheromatous plaque fragments, 32 aorta fragments, and 21 valve fragments) collected from patients in the Amazon region of Brazil.
Used a tissue microarray technique on paraffin-embedded tissues to perform immunohistochemical staining for IL-6, IL-8, TNF-α, IFN-γ, TGF-β, and IL-10.
TNF-α was the most prevalent marker, detected in 91.7% (55/60) of evaluated samples.
Mean percent area stained for TNF-α was significantly higher in patients infected with C. pneumoniae compared to uninfected individuals (3.81% vs 1.92%; p=0.0115), especially in aortic tissue (4.83% vs 2.25%; p=0.0025).
No statistically significant difference in overall cytokine staining profiles was observed between patients infected with both Chlamydia species and uninfected patients.

Cite This Study

Freitas et al. (2017) studied this question.

synapsesocial.com/papers/6a1be25c1567d2fc4d5f3299 https://doi.org/10.2147/idr.s123801

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Implication

Observational biopsy study detects Chlamydia antigens and elevated TNF-α in cardiovascular tissues, suggesting persistent infection may contribute to vascular inflammation.

In situ detection of Chlamydia pneumoniae,C. trachomatis,and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Discussion

Member takes

Implication

Key Points

Cite This Study

In situ detection of Chlamydia pneumoniae,C. trachomatis,and cytokines among cardiovascular diseased patients from the Amazon region of Brazil

Discussion

Member takes

Implication

Key Points

Cite This Study

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