Why the study?
Does physical inactivity alter blood-borne factors and endothelial cell functions differently in men and women?
Does physical inactivity alter blood-borne factors and endothelial cell functions differently in men and women?
Physical inactivity induces sex-specific detrimental alterations in circulating factors that impair endothelial function, highlighting mechanisms by which exercise protects vascular health.
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May indicate sex-specific effects of inactivity on endothelial function; leaves open translation to human exercise recommendations.
Serum from sedentary women caused impaired endothelial migration, whereas serum from sedentary men elicited increased endothelial reactive oxygen species production as compared with serum from their endurance-trained counterparts. Select CVD-related circulating microRNAs (ci-miRs) were higher in men than women, while ci-miRs-140-5p and 145-5p were also higher in sedentary versus trained men and/or women. Our data suggest that alterations in circulating factors may contribute to the protective effects of habitual exercise and sex on vascular health.
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Sapp et al. (2020) studied this question.
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