Key result
Men who maintained a metabolically healthy status over 25 years had significantly better microvascular endothelial function (mean RHI 2.06 vs 1.91) compared to those who became metabolically unhealthy.
Why the study?
Does maintaining a metabolically healthy status improve microvascular endothelial function and cardiovascular biomarkers in middle-aged men?
Population
101 asymptomatic, physically active middle-aged white men, free of chronic diseases and treatment at…
Comparison
Maintenance of metabolically healthy status over… vs Metabolically unhealthy status
Design
Cohort
Follow-up
mean 24.7 years
Authors
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Should not yet change practice; leaves open whether metabolic health maintenance causally improves endothelial outcomes.
Cohort (n=101)
No
Does maintaining a metabolically healthy status improve microvascular endothelial function and cardiovascular biomarkers in middle-aged men?
Absolute Event Rate: 2.06% vs 1.91%
p-value: p=<0.05
Maintaining a metabolically healthy profile through middle adulthood is associated with better microvascular endothelial function and a more favorable inflammatory biomarker profile.
Kwaśniewska et al. (2015) conducted a cohort in Metabolic status and endothelial function (n=101). Maintaining metabolically healthy status vs. Becoming metabolically unhealthy (≥2 metabolic parameters) was evaluated on Reactive hyperemia index (RHI) (p=<0.05). Men who maintained a metabolically healthy status over 25 years had significantly better microvascular endothelial function (mean RHI 2.06 vs 1.91) compared to those who became metabolically unhealthy.
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