Why the study?
Although obesity is a recognized cardiovascular risk factor, the impact of long-term BMI changes in overweight or obese adults on heart failure, CVD, and mortality had not been quantified.
Does stable severe obesity increase the risk of heart failure, cardiovascular disease, and mortality compared to being overweight in adults free from baseline CVD?
Population
264,230 overweight or obese UK adults free from CVD with repeated BMI measures
Comparison
BMI trajectories corresponding to overweight vs class-1, class-2, and class-3 obesity
Design
Population-based cohort study
Follow-up
Median duration of 10.9 years
Authors
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Class-3 obesity was associated with >3-fold HF and mortality risks; leaves open causal effects and intervention benefits in primary prevention.
Does stable severe obesity increase the risk of heart failure, cardiovascular disease, and mortality compared to being overweight in adults free from baseline CVD?
Stable severe obesity over the long term is associated with a substantially increased risk of heart failure, cardiovascular disease, and mortality compared to being overweight.
Iyen et al. (2021) studied this question.