Why the study?
Can observational data from the General Practice Research Database accurately estimate longitudinal changes in blood pressure secondary to drug therapy?
Can observational data from the General Practice Research Database accurately estimate longitudinal changes in blood pressure secondary to drug therapy?
Observational data from the General Practice Research Database, when analyzed with appropriate statistical techniques like linear mixed models and multiple imputation, can reliably estimate blood pressure changes secondary to drug therapy, mirroring clinical trial results.
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GPRD mixed models may estimate drug BP effects; supports observational pharmacoepidemiology but leaves open prospective validation.
Delaney et al. (2008) studied this question.
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