Key result
Treatment with warfarin did not significantly increase blood pressure in men with atrial fibrillation, but pulse pressure increased in those with prior hypertension (P=0.022).
Why the study?
Does warfarin increase systolic blood pressure and pulse pressure in men with nonrheumatic atrial fibrillation?
RCT (n=284)
double-blind
randomized
Does warfarin increase systolic blood pressure and pulse pressure in men with nonrheumatic atrial fibrillation?
p-value: p=NS
Warfarin therapy does not increase blood pressure overall in men with atrial fibrillation, but may increase pulse pressure in those with pre-existing hypertension.
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Warfarin not linked to higher BP in AF men; leaves open pulse pressure rise in prior hypertension, needing prospective confirmation.
KRISHNAN et al. (2005) conducted an RCT in nonrheumatic atrial fibrillation (n=284). Warfarin vs. Placebo was evaluated on systolic blood pressure (SBP) and pulse pressure (PP) (p=NS). Treatment with warfarin did not significantly increase blood pressure in men with atrial fibrillation, but pulse pressure increased in those with prior hypertension (P=0.022).
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