Why the study?
Does low-intensity anticoagulation with warfarin prevent cerebral infarction in men with chronic nonrheumatic atrial fibrillation?
Population
571 men with chronic nonrheumatic atrial fibrillation
Comparison
Low-intensity anticoagulation with warfarin vs Placebo
Design
RCT, randomized, double-blind
Follow-up
average 1.7 to 1.8 years
Authors
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Supports low-intensity warfarin for primary stroke prevention in nonrheumatic AF; extends RCT evidence to men without prior stroke.
Does low-intensity anticoagulation with warfarin prevent cerebral infarction in men with chronic nonrheumatic atrial fibrillation?
Low-intensity anticoagulation with warfarin significantly reduces the risk of cerebral infarction in men with chronic nonrheumatic atrial fibrillation without producing an excess risk of major hemorrhage.
Ezekowitz et al. (1992) studied this question.
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