Key result
Oral anticoagulant therapy with warfarin reduces the risk of ischaemic stroke by 68% in patients with nonvalvular atrial fibrillation, whereas INR values below 2.0 are not effective.
Why the study?
Does oral anticoagulation with warfarin or aspirin prevent ischaemic stroke in patients with nonvalvular atrial fibrillation?
Population
Patients with chronic nonvalvular atrial fibrillation
Comparison
Oral anticoagulant therapy with warfarin or… vs Placebo, low-intensity warfarin, or…
Design
Review
Authors
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Reinforces warfarin (INR 2.0-3.0) for high-risk nonvalvular AF; confirms prior trial data while leaving optimal low-risk strategies open.
Does oral anticoagulation with warfarin or aspirin prevent ischaemic stroke in patients with nonvalvular atrial fibrillation?
Warfarin at an INR of 2.0-3.0 is recommended for stroke prevention in high-risk patients with nonvalvular atrial fibrillation, while aspirin may be used in low-risk patients under 65.
Koefoed et al. (1999) conducted a review in Chronic nonvalvular atrial fibrillation. Oral anticoagulant therapy with warfarin vs. Placebo or aspirin was evaluated on Ischaemic stroke. Oral anticoagulant therapy with warfarin reduces the risk of ischaemic stroke by 68% in patients with nonvalvular atrial fibrillation, whereas INR values below 2.0 are not effective.
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