What does this research mean for the field?

The absence of cardiac myosin binding protein-C (cMyBP-C) enhances myocardial contractile efficiency, likely by reducing internal viscous load and increasing phosphate-dependent oscillatory work. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 25, 2004Circulation ResearchOpen Access

Effect of Cardiac Myosin Binding Protein-C on Mechanoenergetics in Mouse Myocardium

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Population

Wild-type (+/+) and homozygous-truncated cMyBP-C (t/t) mice fed a 6-week diet of 0.15%…

Comparison

Homozygous-truncated cMyBP-C (t/t(PTU)) vs Wild-type (+/+(PTU))

Design

Preclinical

Follow-up

6 weeks

Authors

BPBradley M. PalmerUniversity of Vermont TNTeruo NoguchiCardiac Imaging YWYuan WangFirst Affiliated Hospital Zhejiang University

Discussion

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Implication

Hypothesis-generating for cMyBP-C modulation of efficiency; leaves open translation to human therapies.

Structured PICO

Population

Wild-type (+/+(PTU)) and homozygous-truncated cMyBP-C (t/t(PTU)) mice fed a 6-week diet of 0.15% 6-n-propyl-2-thiouracil (PTU) starting at age approximately 8 weeks

Intervention

Homozygous-truncated cMyBP-C (t/t(PTU))

Comparator

Wild-type (+/+(PTU))

Outcome

Contractile efficiency (converting O2 to mechanical energy) in isovolumically contracting left ventriclesurrogate

The absence of cMyBP-C enhances contractile efficiency in mouse myocardium by reducing viscous load and increasing phosphate-dependent oscillatory work.

Cite This Study

Palmer et al. (2004) studied this question.

synapsesocial.com/papers/6a1be653ea84844e355f261b https://doi.org/10.1161/01.res.0000132744.08754.f2

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Effect of Cardiac Myosin Binding Protein-C on Mechanoenergetics in Mouse Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Cardiac Myosin Binding Protein-C on Mechanoenergetics in Mouse Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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