December 1, 1987European Heart Journal
Effects of quinidine on ventricular repolarization
Why the study?
Does intravenous quinidine increase dispersion of ventricular repolarization in anaesthetized dogs?
Population
Anaesthetized dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Challenges dispersion hypothesis for quinidine torsades; leaves alternative mechanisms open in this animal model.
Structured PICO
Does intravenous quinidine increase dispersion of ventricular repolarization in anaesthetized dogs?
P
Population
Anaesthetized dogs
I
Intervention
Increasing doses of intravenous quinidine
O
Outcome
Monophasic action potential duration and ventricular effective refractory period at several right ventricular myocardial sitessurrogate
Quinidine uniformly prolongs ventricular repolarization in a canine model, suggesting mechanisms other than direct dispersion of repolarization cause quinidine-induced torsade de pointes.
Cite This Study
Brugada et al. (1987) studied this question.