Why the study?
Does doxepin administration cause torsade de pointes?
Does doxepin administration cause torsade de pointes?
Small amounts of doxepin can induce torsade de pointes even with a normal QT interval, highlighting the need to evaluate for this arrhythmia in patients taking doxepin who present with syncope.
Answers are grounded in this paper and cite their sources.
Doxepin may trigger TdP even with normal QT; case-level replication leaves broader causality and screening implications open.
A case of torsade de pointes with normal QT interval secondary to the administration of small amounts of doxepin is presented. Electrophysiological studies during rechallenge with doxepin demonstrated replication of the patient's spontaneous arrhythmia. Evaluation of syncope in patients taking doxepin should include careful evaluation for torsade de pointes.
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STRASBERO et al. (1982) studied this question.
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