What question did this study set out to answer?

This research investigates the mechanisms of torsades de pointes in patients without transient abnormalities. It aims to identify the nature and potential triggers of this arrhythmia.

May 1, 1981CirculationOpen Access

Torsades de pointes: electrophysiologic studies in patients without transient pharmacologic or metabolic abnormalities.

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Why the study?

What are the electrophysiologic characteristics and inducibility of torsades de pointes in patients without transient pharmacologic or metabolic abnormalities?

Population

21 patients with a history of torsades de pointes occurring in the absence of electrolyte disturbance…

Design

Case_series

Authors

LHLeonard N. HorowitzElectrophysiology AGAllan M. GreenspanEinstein Medical Center Philadelphia SSScott R. SpielmanChildren's Hospital of Philadelphia

Discussion

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Implication

May indicate reentry in non-triggered torsades; hypothesis-generating and should not change practice.

Key Points

This research investigates the mechanisms of torsades de pointes in patients without transient abnormalities. It aims to identify the nature and potential triggers of this arrhythmia.
Performed electrophysiologic studies on 21 patients with torsades de pointes.
Involved ventricular pacing with 1 to 3 extrastimuli and rapid pacing.
Assessed the effects of intravenous procainamide or quinidine on arrhythmia outcomes.
Torsades de pointes was inducible in 19 of 21 patients.
Three patients progressed to ventricular tachycardia, and four to ventricular fibrillation after episodes of torsades de pointes.
Procainamide or quinidine successfully converted torsades de pointes to typical reentrant ventricular tachycardia in eight patients.

Structured PICO

What are the electrophysiologic characteristics and inducibility of torsades de pointes in patients without transient pharmacologic or metabolic abnormalities?

Population

21 patients with a history of torsades de pointes occurring in the absence of electrolyte disturbance, antiarrhythmic drug therapy, or acute ischemia.

Intervention

Electrophysiologic study including ventricular pacing with the introduction of one to three extrastimuli and rapid ventricular pacing, along with the administration of i.v. procainamide or quinidine.

Outcome

Inducibility of torsades de pointes during electrophysiologic study.surrogate

In patients without transient metabolic or pharmacologic triggers, torsades de pointes is highly inducible and may represent a rapid reentrant ventricular tachycardia capable of progressing to ventricular fibrillation.

Cite This Study

Horowitz et al. (1981) studied this question.

synapsesocial.com/papers/6a0fd511d8c5cf602efd3813 https://doi.org/10.1161/01.cir.63.5.1120

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Torsades de pointes: electrophysiologic studies in patients without transient pharmacologic or metabolic abnormalities.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Torsades de pointes: electrophysiologic studies in patients without transient pharmacologic or metabolic abnormalities.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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