What does this research mean for the field?

The nonclassical renin-angiotensin system, primarily the AngII/Ang III-AT2R and ACE2-Ang-(1-7)-AT7R axes, opposes the classical RAS to mediate vasodilation and renal protection, contributing to both normal renal function and the therapeutic effects of classical RAS blockade. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 19, 2012Comprehensive physiology

Nonclassical Renin‐Angiotensin System and Renal Function

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Authors

MCMark C. ChappellHeart Failure & Transplant

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Implication

Does not alter current RAS inhibitor use; leaves open targeted nonclassical pathway trials for hypertension and CKD.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Mark C. Chappell (2012) studied this question.

synapsesocial.com/papers/6a1be8fbfc87fd06169cea72 https://doi.org/10.1002/cphy.c120002

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Nonclassical Renin‐Angiotensin System and Renal Function

Discussion

Member takes

Implication

Key Points

Cite This Study

Nonclassical Renin‐Angiotensin System and Renal Function

Discussion

Member takes

Implication

Key Points

Cite This Study

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