What does this research mean for the field?

Approximately 40-50% of human atrial myofibroblasts express a functional sodium current (INa) that is likely generated by a combination of Nav 1.9, Nav 1.2, and Nav 1.5 subunits, suggesting these cells play an active role in cardiac arrhythmias. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 7, 2014Frontiers in PhysiologyOpen Access

Na+ current expression in human atrial myofibroblasts: identity and functional roles

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Authors

JKJussi T. KoivumäkiTampere University RCRobert B. ClarkGovernment of the United States of America DBDarrell D. BelkeElectrophysiology

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Implication

May inform atrial fibrosis electrophysiology models; leaves open functional role in arrhythmogenesis.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Koivumäki et al. (2014) studied this question.

synapsesocial.com/papers/6a1be908ea84844e355f2ac7 https://doi.org/10.3389/fphys.2014.00275

Topics

Atrial fibrillation Persistent AF management

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Na+ current expression in human atrial myofibroblasts: identity and functional roles

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Na+ current expression in human atrial myofibroblasts: identity and functional roles

Discussion

Member takes

Implication

Key Points

Cite This Study

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