What does this research mean for the field?

Smooth muscle inward rectifying potassium (KIR) channels facilitate cell-to-cell communication along skeletal muscle resistance arteries by increasing their activity as the cell hyperpolarizes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 15, 2006AJP Heart and Circulatory Physiology

Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries

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Population

Hamster retractor muscle feed arteries and a computational model of vascular communication

Comparison

KIR channel blockade with 100 microM Ba2+ vs Control conditions and ATP-sensitive- and…

Design

Preclinical

Authors

MJMicaela C. JantziHeritage Medical Research Clinic SBSuzanne E. BrettWestern University WJWilliam F. JacksonMichigan State University

Discussion

Member takes

Implication

KIR channels support conducted responses in skeletal muscle resistance arteries; hypothesis-generating for vascular physiology with no immediate clinical implications.

Structured PICO

Population

Hamster retractor muscle feed arteries and a computational model of vascular communication

Intervention

KIR channel blockade with 100 microM Ba2+

Comparator

Control conditions and ATP-sensitive- and large-conductance Ca2+ activated-K+ channel inhibitors

Outcome

Conduction of acetylcholine-induced vasodilation (index of cell-to-cell communication)surrogate

Smooth muscle KIR channels play a key role in facilitating cell-to-cell communication along skeletal muscle resistance arteries due to their intrinsic property of negative slope conductance.

Cite This Study

Jantzi et al. (2006) studied this question.

synapsesocial.com/papers/6a1be90cea84844e355f2acd https://doi.org/10.1152/ajpheart.00217.2006

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Implication

KIR channels support conducted responses in skeletal muscle resistance arteries; hypothesis-generating for vascular physiology with no immediate clinical implications.

Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider