Aggressive management of blood pressure, glucose, and lipids, along with renin-angiotensin system inhibition, significantly delays the progression of diabetic nephropathy and associated cardiovascular disease.
Supports intensive multifactorial control in diabetes; leaves open need for confirmatory RCTs.
Diabetic nephropathy has become the leading cause of end-stage kidney disease worldwide and is associated with an increased cardiovascular risk. The earliest clinical manifestation is microalbuminuria. Tight blood glucose and blood pressure control reduce the risk of microalbuminuria. Once microalbuminuria is present, the rate of progression to end stage kidney disease and cardiovascular disease can be delayed by aggressive management of blood pressure, glucose, and lipids. Inhibition of the reninangiotensin system is important in reducing intraglomerular pressure but other classes of antihypertensive agents may also be needed to obtain adequate control of systemic blood pressure. Such measures can at least reduce by half the rate of progression of nephropathy and cardiovascular disease.
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E.N. et al. (2019) studied this question.
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