What does this research mean for the field?

Myocardial cells in the developing mouse heart grow via a proliferative mode, rather than a stem cell mode, consisting of an initial dispersive phase followed by coherent, oriented cell growth that prefigures myofibre architecture. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 30, 2003DevelopmentOpen Access

A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart

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Population

Mouse embryos

Design

Preclinical

Authors

SMSigolène M. MeilhacInserm RKRobert G. KellyPediatric / Congenital Cardiology DRDidier RocancourtInstitut Pasteur

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether two-phase myocardial growth prefigures human myofibre architecture.

Structured PICO

Population

Mouse embryos (retrospective clonal analysis of myocardial cells based on targeting an nlaacZ reporter to the alpha-cardiac actin gene)

Intervention

Genetic targeting of an nlaacZ reporter to the alpha-cardiac actin gene

Outcome

Clonal growth patterns of myocardial cells at different developmental stages

Retrospective clonal analysis in mouse embryos demonstrates that myocardial cells grow in two distinct phases (dispersive followed by coherent), which prefigures the architecture of cardiac myofibres.

Cite This Study

Meilhac et al. (2003) studied this question.

synapsesocial.com/papers/6a1beba26f692abb725ef823 https://doi.org/10.1242/dev.00580

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Ask AI

Bookmark

A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider