Why the study?
Does pregnancy or pregnancy loss at an advanced maternal age worsen postpartum vascular function in a rat model?
Population
Reproductively aged rats at approximately 13.5 months of age (3 months postpartum or equivalent)
Comparison
Pregnancy or pregnancy loss vs Never pregnant (virgin) rats
Design
Preclinical
Follow-up
3 months postpartum or equivalent
Authors
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Hypothesis-generating for vascular effects of pregnancy loss in aged rats; leaves open translation to human cardiovascular risk.
Does pregnancy or pregnancy loss at an advanced maternal age worsen postpartum vascular function in a rat model?
In a reproductively aged rat model, pregnancy loss causes worsened vascular pathology, and postpartum rats exhibit distinct vascular dysfunction, suggesting mechanisms for later life cardiovascular risk.
Morton et al. (2017) studied this question.