What does this research mean for the field?

The canine cardiac sarcoplasmic reticulum contains two distinct ATP-dependent calcium binding sites (Site A and Site B) that mediate different phases of the calcium binding-release cycle and exhibit distinct magnesium requirements, nucleotide specificities, and sensitivities to inhibitors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1973Journal of Biological ChemistryOpen Access

Analysis of Calcium Binding and Release by Canine Cardiac Relaxing System (Sarcoplasmic Reticulum)

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Population

Canine cardiac relaxing system preparation (sarcoplasmic reticulum)

Design

Preclinical

Authors

MEMark L. EntmanHeart Failure & Transplant TST. R. SnowBaylor College of Medicine DFDebow FreedVancouver General Hospital

Discussion

Member takes

Implication

Should not yet alter clinical practice; hypothesis-generating for distinct calcium binding sites in cardiac sarcoplasmic reticulum.

Structured PICO

Population

Canine cardiac relaxing system preparation (sarcoplasmic reticulum)

Intervention

ATP and various inhibitors (X537A, arsenate, sodium azide)

Outcome

Kinetics of ATP-dependent calcium binding and releasesurrogate

This preclinical study identifies two distinct calcium binding sites in the canine cardiac sarcoplasmic reticulum with differing kinetic properties and sensitivities to inhibitors.

Cite This Study

Entman et al. (1973) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47c2 https://doi.org/10.1016/s0021-9258(19)43254-7

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Analysis of Calcium Binding and Release by Canine Cardiac Relaxing System (Sarcoplasmic Reticulum)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of Calcium Binding and Release by Canine Cardiac Relaxing System (Sarcoplasmic Reticulum)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider