What does this research mean for the field?

An early invasive strategy for unstable coronary artery disease reduces the rate of death and myocardial infarction compared to a non-invasive strategy, but incurs significantly higher total costs, resulting in an incremental cost-effectiveness ratio of SEK 645,000 per avoided event. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the cost-effectiveness of an early invasive strategy compared to a non-invasive strategy in patients with unstable coronary artery disease.

January 1, 2002European Heart JournalOpen Access

Cost-effectiveness of an invasive strategy in unstable coronary artery disease. Results from the FRISC II invasive trial

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Why the study?

Does an early invasive strategy reduce death and myocardial infarction in patients with unstable coronary artery disease?

Population

2457 patients with unstable coronary artery disease, median age 66 years, 70% men

Comparison

Early invasive strategy vs Non-invasive strategy

Design

RCT, randomized

Follow-up

12 months

Authors

MJMagnus JanzonInterventional Cardiology

Discussion

Member takes

Implication

Supports early invasive strategy in unstable CAD; confirms FRISC II benefits with cost-effectiveness data.

Key Points

This research aims to evaluate the cost-effectiveness of an early invasive strategy compared to a non-invasive strategy in patients with unstable coronary artery disease.
Randomized trial involving 2457 patients, median age 66 years, with 70% men
Prospective recording of health service utilization
Analysis conducted from a societal perspective
1.7% absolute reduction in deaths in the invasive group (p<0.001)
3.7% absolute reduction in both deaths and myocardial infarctions in the invasive group after 12 months
Incremental cost-effectiveness ratio of SEK 1,404,000 per avoided death and SEK 645,000 per avoided death or myocardial infarction

Structured PICO

Does an early invasive strategy reduce death and myocardial infarction in patients with unstable coronary artery disease?

Population

2457 patients with unstable coronary artery disease, median age 66 years, 70% men

Intervention

Early invasive strategy

Comparator

Non-invasive strategy

Outcome

Composite end-point of death and myocardial infarction as well as costs after 12 monthscomposite

An early invasive strategy in unstable coronary artery disease significantly reduces death and myocardial infarction at 12 months but incurs higher initial costs, resulting in an incremental cost-effectiveness ratio of SEK 645,000 per avoided event.

Cite This Study

Magnus Janzon (2002) studied this question.

synapsesocial.com/papers/6a1beff01567d2fc4d5f49bf https://doi.org/10.1053/euhj.2001.2695

Topics

Coronary artery disease

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Cost-effectiveness of an invasive strategy in unstable coronary artery disease. Results from the FRISC II invasive trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cost-effectiveness of an invasive strategy in unstable coronary artery disease. Results from the FRISC II invasive trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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