Acute Myocardial Infarction; Effects of Thrombolysis on Timi Flow Rate in Infarct Related Artery (Ira) in Patients of St Elevated Acute Myocardial Infarction

Objectives: To determine Post streptokinase TIMI flow grade (rate) in infarctrelated artery (IRA) in ST elevated myocardial infarction patients. Study Design: A nonrandomizedprospective study. Period: Dec-2014 to Dec-2015. Setting: Sheikh Zayed MedicalCollege and Hospital Rahim Yaar Khan. Methods: 113 patients were selected to see poststreptokinase TIMI flow grade in infarct related artery (IRA). The data was analyzed using SPSSVersion 20. Descriptive statistics was used to see and analyze the data. Results: Mean ageof patients was 50.43±9.81 years. There was more males (87.61%) as compared to females(12.39%). After thrombolyzation with streptokinase 23.01% patients were with TIMI grade 0/1(failed perfusion), 45.13% (51) patients with TIMI grade 2 (partial perfusion) and 31.86% patientswith TIMI grade 3 (full perfusion) in infarct related artery. In our study TIMI flow improved tograde 2/3 (partial to complete perfusion) in 76.99% patients. There were 11.73% patients withTIMI 0/1 with 50% ST segment resolved, 8.85% patients with TIMI 0/1 with persisted 50% STsegment, 32.74% patients with TIMI 2 with 50% ST segment resolved, 11.5% (13) patients withTIMI 2 with 50% ST segment persisted, 32.74% patients with TIMI 3 with 50% ST segmentresolved and 4.42% patients with TIMI 3/1 with 50% ST segment persisted. Post streptokinasethere was no coronary artery thrombus in 91.07 % patients. While 6.25% patients had thrombusin left coronary artery and 2.84% patients had right coronary artery thrombus. Conclusion:Thrombolyzation with streptokinase improves perfusion in infarct related artery and increasesTIMI flow grade in STEMI patients. It reduces the risk of recurrent myocardial infarction byrestoration of blood flow in infarct related artery.