Why the study?
With new discoveries expanding treatment options beyond standard neurohormonal blockade for HFrEF, the role of additional personalized therapies requires evaluation.
Population
Patients with HFrEF
Comparison
Ivabradine, nitrate/hydralazine, and digoxin vs control or standard therapy
Design
Systematic review and meta-analysis
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Lima et al. (2022) studied this question.
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