What does this research mean for the field?

Equine platelet beta tropomyosin is a 247-residue protein with specific sequence differences from skeletal muscle alpha tropomyosin—including an N-terminal extension, two internal deletions, and a distinct C-terminus—that correlate with its reduced polymerization and weaker interactions with F-actin and troponin. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 13, 1983FEBS Letters

Amino acid sequence of equine platelet tropomyosin

View Full Paper

Ask AI

Bookmark

Population

Equine platelet beta tropomyosin and rabbit skeletal muscle alpha tropomyosin

Comparison

Amino acid sequencing and structural comparison vs Rabbit skeletal muscle alpha tropomyosin

Design

Preclinical

Authors

WLWilliam G. LewisAlabama State University GCGraham P. CôtéRELX Group (Netherlands)AMAlan S. MakQueen's University

Discussion

Member takes

Implication

Sequence differences may underlie platelet cytoskeletal variation; leaves open translation to human cardiovascular biology.

Structured PICO

Population

Equine platelet beta tropomyosin and rabbit skeletal muscle alpha tropomyosin

Intervention

Amino acid sequencing and structural comparison

Comparator

Rabbit skeletal muscle alpha tropomyosin

Outcome

Amino acid sequence differences and structural variationssurrogate

The study identifies specific amino acid sequence differences between equine platelet and rabbit skeletal muscle tropomyosin that explain the diminished polymerization and weaker protein interactions of the platelet variant.

Cite This Study

Lewis et al. (1983) studied this question.

synapsesocial.com/papers/6a1bf2fc27b545b111a93f02 https://doi.org/10.1016/0014-5793(83)80511-0

View Full Paper

Ask AI

Bookmark

Amino acid sequence of equine platelet tropomyosin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Amino acid sequence of equine platelet tropomyosin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider