Population
Immobilized alpha-tropomyosin model (in vitro protein binding assay)
Comparison
Troponin-I plus-C, troponin-T and its fragments vs Individual components
Design
Preclinical
Authors
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Preclinical only; extends molecular models of thin-filament cooperativity but leaves human translation open.
Troponin-I binding to tropomyosin induces cooperativity that strengthens the binding of troponin-T fragments, likely mediated by a conformational change.
Pearlstone et al. (1983) studied this question.
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