What question did this study set out to answer?

This review aims to analyze and compare pharmacological treatment recommendations for depression from various clinical practice guidelines (CPGs).

April 21, 2020PLoS ONEOpen Access

Pharmacological treatment of depression: A systematic review comparing clinical practice guideline recommendations

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Authors

FGFranciele Cordeiro GabrielUniversidade de Brasília DMDaniela Oliveira de MeloInstituto de Ciências Farmacêuticas RFRenério FráguasHospital Universitário da Universidade de São Paulo

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Implication

Systematic review compares pharmacological treatment recommendations in clinical practice guidelines for depression, indicating key divergences and concerns.

Key Points

This review aims to analyze and compare pharmacological treatment recommendations for depression from various clinical practice guidelines (CPGs).
Included four CPGs with scores ≥ 80% for rigor of development and two additional commonly used CPGs.
Extracted recommendations, strengths, and levels of evidence related to pharmacological treatments for depression.
Grouped recommendations into general treatment protocols, non-responsive patient strategies, and subtype-specific treatments.
Only 50% of CPGs included recommendations for suicide risk associated with pharmacotherapy.
All CPGs recommended serotonin selective reuptake inhibitors (SSRIs) as first-line treatments, with some suggesting additional alternatives like agomelatine and milnacipran.
Differences in the strength of recommendations and evidence levels were observed, particularly for treatment augmentation strategies.

Cite This Study

Gabriel et al. (2020) studied this question.

synapsesocial.com/papers/6a1bf34aea84844e355f3792 https://doi.org/10.1371/journal.pone.0231700

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Implication

Systematic review compares pharmacological treatment recommendations in clinical practice guidelines for depression, indicating key divergences and concerns.

Pharmacological treatment of depression: A systematic review comparing clinical practice guideline recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharmacological treatment of depression: A systematic review comparing clinical practice guideline recommendations

Discussion

Member takes

Implication

Key Points

Cite This Study

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