Reflections on the Global Burden of Disease 2010 Estimates

The Institute for Health Metrics and Evaluation (IHME) and its partners recently completed what is probably the largest ever exercise undertaken in epidemiological modelling, the Global Burden of Disease 2010 (GBD-2010) estimates These estimates attempt to characterise loss of health from disease and injury, including the effects of some major risk factors, on a global basis. They will find widespread use in coming years and influence developments in global health. However, it is important to realise that ''estimates are estimates, and not measurements''; they may perform better in some respects than others Here, as a group of independent experts, we comment on some of the major issues raised by this important work, while noting that it is impossible to cover all the wealth of detail involved in any critique. We take collective responsibility for these views, though many specific points come from individual specialists among the authors.