Why the study?
Does ventilation with PEEP alter left ventricular shape and wall motion in a canine model?
Population
7 dogs with implanted radiopaque markers in the left ventricular wall and septum
Comparison
Ventilation with positive end-expiratory… vs Positive-pressure ventilation without PEEP, and…
Design
Preclinical
Authors
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PEEP may reduce stroke volume via LV lateral wall restriction during ventilation; leaves open translation to clinical practice.
Does ventilation with PEEP alter left ventricular shape and wall motion in a canine model?
PEEP deforms the left ventricle primarily by restricting lateral wall expansion during diastole, likely due to lung compression rather than right ventricular dilation, which contributes to reduced stroke volume.
Cassidy et al. (1984) studied this question.
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