What does this research mean for the field?

Acyclovir-resistant herpes simplex virus (HSV) strains can emerge in patients with AIDS following prolonged acyclovir therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 2, 1989New England Journal of Medicine

Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

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Population

Patients with the acquired immunodeficiency syndrome and recurrent herpes simplex virus infections

Design

Other

Authors

KEKim S. ErlichUniversity of California, San Francisco JMJohn MillsRonald Reagan UCLA Medical Center PCP A ChatisBeth Israel Deaconess Medical Center

Discussion

Member takes

Implication

Potential resistance warrants monitoring in AIDS patients on prolonged acyclovir; leaves open optimal alternative strategies.

Structured PICO

Population

Patients with the acquired immunodeficiency syndrome (AIDS) and recurrent herpes simplex virus (HSV) infections

Intervention

Systemic acyclovir

Acyclovir-resistant strains of HSV can emerge in AIDS patients receiving prolonged acyclovir therapy.

Cite This Study

Erlich et al. (1989) studied this question.

synapsesocial.com/papers/6a1bf77ec97d63156a5f27ff https://doi.org/10.1056/nejm198902023200506

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Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider