Why the study?
Does exposure to supraphysiological glucose alter noradrenaline sensitivity and acetylcholine-induced relaxation in isolated rat mesenteric resistance arteries?
Does exposure to supraphysiological glucose alter noradrenaline sensitivity and acetylcholine-induced relaxation in isolated rat mesenteric resistance arteries?
Hyperglycemia impairs endothelium-dependent relaxation and enhances noradrenaline sensitivity in rat mesenteric arteries, likely mediated by abnormal cyclo-oxygenase activity, reduced nitric oxide, free radicals, and polyol pathway activation.
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Caution against clinical extrapolation from rat vessels; leaves open hyperglycemia mechanisms in human resistance arteries.
Taylor et al. (1994) studied this question.
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