Key result
Cholesterol supplementation for 10 days in hospitalized patients with pulmonary infection significantly improved total cholesterol, nutritional status, and disease severity compared to control (P<0.05).
Why the study?
Does cholesterol supplementation improve nutritional status and disease severity in hospitalized patients with pulmonary infection?
RCT
randomized
No
Does cholesterol supplementation improve nutritional status and disease severity in hospitalized patients with pulmonary infection?
p-value: p=<0.05
Cholesterol supplementation in hospitalized patients with pulmonary infection may improve nutritional status and reduce disease severity.
Cholesterol supplementation warrants consideration in malnourished pulmonary infection patients; extends nutritional repletion trials in acute respiratory illness.
Background: Decreased concentrations of total cholesterol concentration could occur in the course of some illness, especially the infection illness. Low cholesterol concentration has been associated clinically with several adverse outcomes. We conducted a study to supplement cholesterol, and observe the change on the test indexes and the severity of disease. We then further discussed the relationships among the supplementation on cholesterol and pro- and anti- inflammatory cytokines. Methods: A randomized and controlled clinical trial was conducted at the infectious disease department in Beijing Friendship Hospital，Capital Medical University，Beijing. Between January 2011 and December 2012, all hospitalized patients with pulmonary infection were invited. The patients were assigned into intervention group and control group randomly. After 10-day supplementation and observation, we analyzed the changes of clinical measurements. Results: In the intervention group, there were statistically significant increases in concentration of total cholesterol (TC), albumin (ALB), pre albumin ( PA) after 10-day intervention of cholesterol supplementation (P 0.05). Compared the differences on indexes between after 10-day intervention in intervention group and after 10-day observation in control group, the compared data showed that there were significant differences in seven indexes, TC, Body Mass Index (BMI), ALB, PA, CRP, IL-6 and the severity of disease (P<0.05). The increased concentrations of TC, ALB and PA in intervention group were more than those changes in control group. The BMI in intervention group was increased more than that in control group. The decreased concentrations of CRP and IL-6 in intervention group were more than those changes in control group. The improvement of severity of disease in intervention group was more obvious than that in control group. The improvement of nutrition status in intervention group was significant. Conclusion: Infectious disease, especially pneumonia and pulmonary infection disease, can lead to hypocholesterolemia. Supplementation of cholesterol properly can improve the nutritional status, decrease the severity of disease, and improve the prognosis of disease.
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Wang et al. (2016) conducted an RCT in Pulmonary infection with hypocholesterolemia. Cholesterol supplementation vs. Control group (observation) was evaluated on Changes in clinical measurements including TC, BMI, ALB, PA, CRP, IL-6, and severity of disease (p=<0.05). Cholesterol supplementation for 10 days in hospitalized patients with pulmonary infection significantly improved total cholesterol, nutritional status, and disease severity compared to control (P<0.05).
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