Key result
Pulmonary vascular stiffness is an increasingly recognized diagnostic marker in pulmonary vascular disease, with emerging clinical, experimental, and computational methods to measure and model it.
This review highlights the diagnostic importance of pulmonary vascular stiffness and details clinical, experimental, and computational methods for its measurement and modeling.
May enhance pulmonary vascular disease evaluation; leaves open standardization and prospective validation of emerging stiffness metrics.
This article introduces the concept of pulmonary vascular stiffness, discusses its increasingly recognized importance as a diagnostic marker in the evaluation of pulmonary vascular disease, and describes methods to measure and model it clinically, experimentally, and computationally. It begins with a description of systems‐level methods to evaluate pulmonary vascular compliance and recent clinical efforts in applying such techniques to better predict patient outcomes in pulmonary arterial hypertension. It then progresses from the systems‐level to the local level, discusses proposed methods by which upstream pulmonary vessels increase in stiffness, introduces concepts around vascular mechanics, and concludes by describing recent work incorporating advanced numerical methods to more thoroughly evaluate changes in local mechanical properties of pulmonary arteries.
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Hunter et al. (2011) conducted a review in Pulmonary vascular disease and pulmonary arterial hypertension. Measurement and modeling of pulmonary vascular stiffness was evaluated. Pulmonary vascular stiffness is an increasingly recognized diagnostic marker in pulmonary vascular disease, with emerging clinical, experimental, and computational methods to measure and model it.
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