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November 1, 2000Stroke

Prediction of Functional Outcome and In-Hospital Mortality After Admission With Oral Anticoagulant–Related Intracerebral Hemorrhage

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Why the study?

What factors predict functional outcome and in-hospital mortality in patients with oral anticoagulant-related intracerebral hemorrhage?

Population

42 patients admitted with oral anticoagulant-related intracerebral hemorrhage to a tertiary care center in…

Design

Cohort

Follow-up

in-hospital

Authors

JBJoris BerwaertsTufts UniversityRDRoelf S. DijkhuizenUniversity of AberdeenOROlive J. RobbCliniques Universitaires Saint-Luc

Discussion

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Implication

Hematoma diameter and CT cerebrovascular signs may refine short-term prognosis in OAC-ICH; leaves open whether models outperform INR in prospective cohorts.

Key Points

  • This research aims to identify key factors influencing functional outcomes and in-hospital mortality in patients with OAC-related intracerebral hemorrhage.
  • Retrospective analysis of 42 patients admitted with OAC-related intracerebral hemorrhages over 6 years.
  • Correlation studies and multiple logistic regression analyses were performed to determine influences on outcomes.
  • CT scan assessments were utilized to gauge hematoma diameter and cerebrovascular disease signs.
  • Functional outcomes were significantly correlated with hematoma diameter on CT (R:=-0.72, P:<0.001).
  • In-hospital mortality prediction improved with a model including hematoma size (R²=0.70, predictive accuracy 83%).
  • INR did not strongly correlate with functional outcomes or mortality.

Structured PICO

What factors predict functional outcome and in-hospital mortality in patients with oral anticoagulant-related intracerebral hemorrhage?

P
Population
42 patients admitted with oral anticoagulant (OAC)-related intracerebral hemorrhage to a tertiary care center in the north of Scotland over a 6-year period.
O
Outcome
Functional outcome and in-hospital mortalityhard clinical

CT scan findings, specifically hematoma diameter and signs of cerebrovascular disease, are stronger predictors of short-term outcome and in-hospital mortality than admission INR in patients with OAC-related intracerebral hemorrhage.

Cite This Study

Berwaerts et al. (2000) studied this question.

synapsesocial.com/papers/6a1bfdbe26cb5670aa9d38c3https://doi.org/10.1161/01.str.31.11.2558
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The risk of intracerebral hemorrhage during oral anticoagulant treatment: A population study1984 · 214 citations
  2. 2Intracranial traumatic and non-traumatic haemorrhagic complications of warfarin treatment2009 · 67 citations
  3. 3Death and functional outcome after spontaneous intracerebral hemorrhage. A prospective study of 166 cases using multivariate analysis.1991 · 398 citations
  4. 4Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality.1993 · 1,762 citations
  5. 5Anticoagulation-Related Intracerebral Hemorrhage1991 · 23 citations