Key result
Daily troponin I and D-dimer follow-up values were more effective than other inflammatory markers in predicting mortality and the need for intensive care in COVID-19 pneumonia patients (P<0.001).
Why the study?
Limited data were available on cardiovascular manifestations in patients with COVID-19 to clarify the impact of daily troponin I and D-dimer levels on intensive care needs and mortality.
Do daily troponin I and D-dimer serum levels predict mortality and the need for intensive care in patients hospitalized with moderate-to-severe COVID-19 pneumonia?
Observational (n=205)
Do daily troponin I and D-dimer serum levels predict mortality and the need for intensive care in patients hospitalized with moderate-to-severe COVID-19 pneumonia?
Daily monitoring of troponin I and D-dimer levels can effectively predict clinical deterioration, need for intensive care, and mortality in patients with moderate-to-severe COVID-19 pneumonia.
May support serial troponin I and D-dimer monitoring for risk stratification in COVID-19 pneumonia; leaves open need for prospective validation.
BACKGROUND: Coronavirus disease 2019 (COVID-19) is an infection resulting in very high morbidity and mortality rates globally. Limited data are available on the cardiovascular manifestations in these patients. The aim of this study was to analyse the daily troponin I and D-dimer levels and their impact on the need for intensive care and on mortality rates of COVID-19-infected patients. METHODS: Two-hundred and five patients who were hospitalised between 20 March and 5 May 2020, with a diagnosis of moderate-to-severe COVID-19 pneumonia, were analysed retrospectively. Serum troponin I and D-dimer levels were recorded for at least 10 days after admission. CONCLUSIONS: We showed that hospitalisations ≥ 9.5 days in duration were related to increased mortality rates. Troponin I and D-dimer follow-up values in the serum were more effective than other inflammatory markers in predicting mortality and the need for intensive care. A high troponin I value should alert the clinician in terms of clinical deterioration.
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Stavılecı et al. (2023) conducted an observational in moderate-to-severe COVID-19 pneumonia (n=205). Daily troponin I and D-dimer serum levels was evaluated on Mortality and need for intensive care (p=< 0.001). Daily troponin I and D-dimer follow-up values were more effective than other inflammatory markers in predicting mortality and the need for intensive care in COVID-19 pneumonia patients (P<0.001).
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