Key result
Elevated troponin levels at admission were associated with increased in-hospital mortality compared to normal levels (37% vs 13%; HR 1.71; 95% CI 1.13-2.59; P=.01).
Why the study?
Initial data linking elevated troponin to mortality in COVID-19 were from Chinese single- or 2-center studies, whereas European and US patients are older with more comorbidities and higher mortality rates.
Does elevated troponin increase in-hospital mortality in patients hospitalized with COVID-19?
Population
614 patients hospitalized with laboratory-confirmed COVID-19 across 13 Italian cardiology units
Comparison
Elevated vs normal cardiac troponin levels at admission
Design
Multicenter cross-sectional study
Authors
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May flag high-risk COVID-19 inpatients for intensified care but should not yet change practice; leaves open incremental prognostic value.
Cross-Sectional (n=614)
Yes
Does elevated troponin increase in-hospital mortality in patients hospitalized with COVID-19?
Hazard Ratio: 1.71 (95% CI 1.13–2.59)
Absolute Event Rate: 37% vs 13%
p-value: p=.01
Elevated troponin levels at admission are independently associated with higher in-hospital mortality and complications in patients hospitalized with COVID-19.
Lombardi et al. (2020) conducted a cross-sectional in COVID-19 (n=614). Elevated troponin levels vs. Normal troponin levels was evaluated on In-hospital mortality (HR 1.71, 95% CI 1.13-2.59, p=.01). Elevated troponin levels at admission were associated with increased in-hospital mortality compared to normal levels (37% vs 13%; HR 1.71; 95% CI 1.13-2.59; P=.01).