What does this research mean for the field?

Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in non-diabetic individuals, providing predictive value for cardiovascular disease beyond conventional risk factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2000European Heart JournalOpen Access

Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study

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Why the study?

Is microalbuminuria associated with ischaemic electrocardiographic abnormalities in a non-diabetic population?

Population

7579 non-diabetic subjects, ages 28 to 75 years, selected from a population-based cohort.

Design

Cross-sectional

Authors

GDGilles F.H. DiercksUniversity Medical Center Groningen

Discussion

Member takes

Implication

Microalbuminuria may flag subclinical ischaemic risk in non-diabetics; hypothesis-generating and should not yet alter practice.

Key Points

To determine whether microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities and increased cardiovascular risk in non-diabetic individuals.
Evaluated 7,579 non-diabetic individuals aged 28 to 75 years sampled from the population-based PREVEND cohort.
Measured urinary albumin excretion as the mean of two 24-hour urine collections.
Categorized ischaemic electrocardiographic abnormalities into infarct patterns, major ischaemia, and minor ischaemia using computerized Minnesota coding, adjusting for major cardiovascular risk factors.
Microalbuminuria demonstrated an independent association with electrocardiographic infarct patterns (OR 1.61, 95% CI 1.12–2.32) after adjusting for age, sex, hypertension, cholesterol, smoking, obesity, and family history.
Microalbuminuria was independently associated with major ischaemia (OR 1.43, 95% CI 1.08–1.91) and minor ischaemia (OR 1.32, 95% CI 1.03–1.68) in multivariate analysis.

Structured PICO

Is microalbuminuria associated with ischaemic electrocardiographic abnormalities in a non-diabetic population?

Population

7579 non-diabetic subjects, ages 28 to 75 years, selected from a population-based cohort.

Intervention

Microalbuminuria (measured as the mean of two 24-h urine collections)

Outcome

Ischaemic electrocardiographic abnormalities (infarct patterns, major ischaemia, and minor ischaemia) assessed by computerized Minnesota codingsurrogate

Microalbuminuria is independently associated with ischaemic ECG abnormalities in non-diabetics, suggesting its potential utility as an early marker for coronary vascular disease risk.

Cite This Study

Gilles F.H. Diercks (2000) studied this question.

synapsesocial.com/papers/6a1bfffb4cc49ccc94a900ca https://doi.org/10.1053/euhj.2000.2248

Topics

Women and heart disease

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