Breast Cancer in Women Younger Than 35 Years Old: Immunohistochemical and Molecular Characteristics and Imaging Diagnosis

The aim of this study was to characterize imaging, immunohistochemical and molecular breast cancer in women younger than 35 years old.Material and methods: In this retrospective study, data were collected from 46 patients under the age of 35, out of a total of 1,854 patients diagnosed with breast cancer between May 2012 and February 2019 at the Regional Institute of Oncology Iasi (Department of Surgery).The following tumor characte ristics were evaluated: tumor size, histological type, molecular subtype, histological grade, nodal status and the presence of systemic metastases.Results: Of the 46 cases, invasive ductal carcinoma was the most common histological type (n=31, 67.39%).More than half of the tumors were ER + (n=36, 78.26%) and PR + (n=33, 71.73%).In 84.78% of cases (n=39) we observed a high expression of Ki67 proliferation index (> 20%).Luminal genomic B subtype was the most common (n=27, 58.69%), and triple negative breast cancer was 13.04% (n=6).Conclusions: Breast tumors in young women (under the age of 35) have a much more aggressive tumor biology.Future research is required to investigate new treatment strategies especially in young breast cancer patients.