What does this research mean for the field?

Prosthetic valve endocarditis occurs in approximately 3.6% of valve replacement survivors, carries a high mortality rate of 64%, and is significantly predicted by prior native valve endocarditis, black race, mechanical prosthesis use, and male sex. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the incidence, risk factors, clinical characteristics, and survival outcomes of prosthetic valve endocarditis following heart valve replacement.

February 1, 1984CirculationOpen Access

Prosthetic valve endocarditis.

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Why the study?

What are the incidence and risk factors for developing prosthetic valve endocarditis after valve replacement?

Key Points

To determine the incidence, risk factors, clinical characteristics, and survival outcomes of prosthetic valve endocarditis following heart valve replacement.
Followed a cohort of 1,465 consecutive in-hospital survivors of aortic, mitral, or double-valve replacement performed between 1975 and July 1979.
Evaluated clinical presentation, timing of infection, microbiological findings, and multivariable risk factors for prosthetic valve endocarditis across up to 48 months of follow-up.
Prosthetic valve endocarditis developed in 53 patients (3.6%; actuarial rate 4.1% at 48 months), with risk peaking at 3 weeks post-surgery.
Incremental risk factors included prior native valve endocarditis (p < 0.0001), Black race (p = 0.0001), mechanical prosthesis versus bioprosthesis (p = 0.005), male sex (p = 0.04), and longer cardiopulmonary bypass duration (p = 0.09).
Mortality was 64% (34 of 53 patients died), with the vast majority of deaths occurring within 3 months of infection onset.

Structured PICO

What are the incidence and risk factors for developing prosthetic valve endocarditis after valve replacement?

Population

1465 consecutive in-hospital survivors of valve replacement (aortic, mitral, or aortic and mitral) from 1975 to July 1979

Outcome

Development of prosthetic valve endocarditis (PVE)hard clinical

Prosthetic valve endocarditis is a highly lethal complication occurring in approximately 3.6% of valve replacement survivors, with prior native endocarditis and mechanical prostheses being significant risk factors.

Discussion

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Implication

Supports risk stratification after valve replacement; leaves open need for prospective validation of preventive strategies.

Cite This Study

Ivert et al. (1984) studied this question.

synapsesocial.com/papers/6a1c03d1bc71fb1015a92b7e https://doi.org/10.1161/01.cir.69.2.223

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Prosthetic valve endocarditis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Prosthetic valve endocarditis.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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