Average-case hardness of NP from exponential worst-case hardness assumptions

A long-standing and central open question in the theory of average-case complexity is to base average-case hardness of NP on worst-case hardness of NP. A frontier question along this line is to prove that PH is hard on average if UP requires (sub-)exponential worst-case complexity. The difficulty of resolving this question has been discussed from various perspectives based on technical barrier results, such as the limits of black-box reductions and the non-existence of worst-case hardness amplification procedures in PH.