Key result
Left atrial appendage structural and hemodynamic characteristics, including non-chicken wing shape, larger orifice, and lower flow velocity, are associated with increased stroke risk in patients with atrial fibrillation.
Why the study?
Common stroke risk stratification models like the CHA2DS2-VASc score do not incorporate structural or hemodynamic features of the left atrial appendage, despite its role as a common site of thrombus formation in AF.
Answers are grounded in this paper and cite their sources.
Incorporating LAA geometrical and hemodynamic features into stroke risk stratification models may improve the identification of high-risk AF patients for anticoagulant therapy.
Left atrial appendage (LAA) is believed to be a common site of thrombus formation in patients with atrial fibrillation (AF). However, the commonly-applied stroke risk stratification model (such as. CHA 2 DS 2 -VASc score) does not include any structural or hemodynamic features of LAA. Recent studies have suggested that it is important to incorporate LAA geometrical and hemodynamic features to evaluate the risk of thrombus formation in LAA, which may better delineate the AF patients for anticoagulant administration and prevent strokes. This review focuses on the LAA-related factors that may be associated with thrombus formation and cardioembolic events.
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Fang et al. (2022) conducted a review in Atrial fibrillation. Left atrial appendage structural and hemodynamic characteristics, including non-chicken wing shape, larger orifice, and lower flow velocity, are associated with increased stroke risk in patients with atrial fibrillation.
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