A 5-month endurance exercise training intervention significantly decreased ANGPTL3/8 levels, corresponding with improvements in LPL activity, plasma triglycerides, and visceral fat (all p<5.1x10-4).
Cohort (n=642)
Does a 5-month endurance exercise training intervention improve ANGPTL3/8, ANGPTL4/8, lipase activities, and cardiometabolic traits in adults?
A 5-month endurance exercise training intervention decreases ANGPTL3/8 and ANGPTL4/8 levels, which correlates with improvements in lipase activity and cardiometabolic risk factors.
p-value: p=<5.1x10-4
Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown. We characterized ANGPTL3/8 and ANGPTL4/8 and their relationship with in vivo measurements of lipase activities and cardiometabolic traits before and after a 5 month endurance exercise training intervention in 642 adults from the HERITAGE Family Study. At baseline, higher levels of both ANGPTL3/8 and ANGPTL4/8 were associated with a worse lipid, lipoprotein, and cardiometabolic profile, with only ANGPTL3/8 associated with post-heparin LPL and HL activities. ANGPTL3/8 significantly decreased with exercise training, which corresponded with increases in LPL activity and decreases in HL activity, plasma triglycerides, apoB, visceral fat, and fasting insulin (all p<5.1x10-4). Exercise-induced changes in ANGPTL4/8 were directly correlated to concomitant changes in total cholesterol, LDL-C, apoB, and HDL-triglycerides and inversely related to change in insulin sensitivity index (all p<7.0x10-4). In conclusion, exercise-induced decreases in ANGPTL3/8 and ANGPTL4/8 were related to concomitant improvements in lipase activity, lipid profile, and cardiometabolic risk factors. These findings reveal the ANGPTL3-4-8 model as a potential molecular mechanism contributing to adaptations in lipid metabolism in response to exercise training.
Hoffmann et al. (Fri,) conducted a cohort in Dyslipidemia and cardiometabolic risk (n=642). Endurance exercise training vs. Baseline (before intervention) was evaluated on Changes in ANGPTL3/8 and ANGPTL4/8 and their relationship with in vivo measurements of lipase activities and cardiometabolic traits (p=<5.1x10-4). A 5-month endurance exercise training intervention significantly decreased ANGPTL3/8 levels, corresponding with improvements in LPL activity, plasma triglycerides, and visceral fat (all p<5.1x10-4).