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May 26, 1967Science

Synaptic Loci on Parietal Cortical Neurons: Terminations of Corpus Callosum Fibers

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Authors

AGAlbert GlobusASArnold B. Scheibel

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Overview

Animal experiment demonstrates selective dendritic spine loss on oblique apical dendrites in rabbits, revealing precise corpus callosum synaptic targets.

Key Points

  • Map the specific synaptic termination sites of corpus callosum axonal projections onto parietal cortical neurons by assessing dendritic spine loss after tract transection.
  • Surgically sectioned the corpus callosum at birth in neonatal rabbits (N=5).
  • Assessed and compared dendritic spine density on parietal cortex neurons against controls at 30 days of age.
  • Loss of dendritic spines was strictly localized to the oblique branches of apical dendrites in parietal cortex neurons.
  • Spine density remained preserved across other dendritic compartments, establishing that callosal afferent fibers terminate selectively on these oblique branches.

Cite This Study

Globus et al. (1967) studied this question.

synapsesocial.com/papers/6a1c062cd54006be995f6c2fhttps://doi.org/10.1126/science.156.3778.1127
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