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February 1, 1995Journal of Biological ChemistryOpen Access

Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle

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Population

Cardiac calcium release channel of sarcoplasmic reticulum vesicles incorporated into planar lipid membranes

Comparison

Sequential and multiple treatments with highly… vs Dephosphorylated state

Design

Preclinical

Authors

JHJ HainHOHitoshi OnoueMMM. Mayrleitner

Discussion

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Overview

Highlights nuanced Ca release channel regulation in animals; leaves open net effects on human excitation-contraction coupling.

Structured PICO

P
Population
Cardiac calcium release channel (CRC) of sarcoplasmic reticulum vesicles incorporated into planar lipid membranes
I
Intervention
Sequential and multiple treatments with highly purified kinases (protein kinase A [PKA], Ca/calmodulin-dependent protein kinase II [CalPK]) and phosphatases (potato acid phosphatase, protein phosphatase 1)
C
Comparator
Dephosphorylated state
O
Outcome
Modulation of channel activity (activation, closure, and Mg block)surrogate

Phosphorylation of the cardiac calcium release channel is essential for its activation at physiological magnesium concentrations, providing insights into the regulation of cardiac excitation-contraction coupling.

Cite This Study

Hain et al. (1995) studied this question.

synapsesocial.com/papers/6a1c075e4ebd09f3dfa95b0chttps://doi.org/10.1074/jbc.270.5.2074
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