Key result
Contact force below 10.5 g adjacent to the carina predicts RPV breakthrough during AI-guided PVI.
Why the study?
Carina breakthrough at the RPV can occur after circumferential PVI, and surrogate ablation parameters to predict RPV CB during AI-guided PVI with HPSD are not well established.
Does lower contact force predict right pulmonary vein carina breakthrough in patients undergoing AI-guided PVI with HPSD for atrial fibrillation?
Observational (n=62)
Does lower contact force predict right pulmonary vein carina breakthrough in patients undergoing AI-guided PVI with HPSD for atrial fibrillation?
Effect estimate: AUC 0.714
In patients undergoing AI-guided PVI with HPSD, maintaining a contact force ≥ 10.5 g adjacent to the carina may reduce the risk of right pulmonary vein carina breakthrough.
Contact force <10.5 g was associated with right pulmonary vein carina breakthrough; hypothesis-generating for force targets in AI-guided PVI and requires prospective validation.
INTRODUCTION: Carina breakthrough (CB) at the right pulmonary vein (RPV) can occur after circumferential pulmonary vein isolation (PVI) due to epicardial bridging or transient tissue edema. High-power short-duration (HPSD) ablation may increase the incidence of RPV CB. Currently, the surrogate of ablation parameters to predict RPV CB is not well established. This study investigated predictors of RPV CB in patients undergoing ablation index (AI)-guided PVI with HPSD. METHODS: The study included 62 patients with symptomatic atrial fibrillation (AF) who underwent AI-guided PVI using HPSD. Patients were categorized into two groups based on the presence or absence of RPV CB. Lesions adjacent to the RPV carina were assessed, and CB was confirmed through residual voltage, low voltage along the ablation lesions, and activation wavefront propagation. RESULTS: Out of the 62 patients, 21 (33.87%) experienced RPV CB (Group 1), while 41 (66.13%) achieved first-pass RPV isolation (Group 2). Despite similar AI and HPSD, patients with RPV CB had lower contact force (CF) at lesions adjacent to the RPV carina. Receiver operating characteristic (ROC) curve analysis identified CF < 10.5 g as a predictor of RPV CB, with 75.7% sensitivity and 56.2% specificity (area under the curve: 0.714). CONCLUSION: In patients undergoing AI-guided PVI with HPSD, lower CF adjacent to the carina was associated with a higher risk of RPV CB. These findings suggest that maintaining higher CF during ablation in this region may reduce the occurrence of RPV CB.
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Chen et al. (2023) conducted an observational in symptomatic atrial fibrillation (AF) (n=62). Contact force (CF) < 10.5 g was evaluated on Right pulmonary vein carina breakthrough (RPV CB) (AUC 0.714). Contact force < 10.5 g adjacent to the carina predicted right pulmonary vein carina breakthrough during AI-guided PVI with 75.7% sensitivity and 56.2% specificity (AUC 0.714).
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