Key result
Wider RPV carina region linked to ~3.5-fold higher odds of epicardial connections.
Why the study?
The anatomical features that can predict an epicardial connection between the right pulmonary vein and right atrium needed to be elucidated.
Cohort (n=251)
No
Odds Ratio: 3.49 (95% CI 1.295–9.388)
p-value: p=0.013
Anatomical features on pre-procedural CT, including a wider RPV bifurcation angle and larger carina area ratio, can independently predict the presence of right pulmonary vein epicardial connections requiring additional ablation during AF isolation.
May aid pre-procedural identification of epicardial connections; hypothesis-generating in one retrospective cohort and requires prospective validation.
Background This study thought to elucidate the anatomical features that can predict an epicardial connection (EC) between the right pulmonary vein (RPV) and right atrium. Methods We retrospectively analyzed 251 consecutive patients undergoing initial radiofrequency pulmonary vein isolation. We defined EC as present when RPV could not be isolated with circumferential ablation and additional ablation for the conduction gap if needed, and RPV isolation could be achieved by ablation for the earliest activation site >10 mm inside the initial ablation line. Using computed tomography data, we evaluated the RPV bifurcation angle, and the area occupation ratio of the carina region to the RPV antrum (ARC) for predicting EC. In subjects with EC undergoing RPV activation mapping after circumferential ablation, the correlation between conduction delay and bipolar/unipolar potential voltage in the carina region was investigated. Results There were ECs in 45 out of 251 patients (17.9%). The RPV bifurcation angle (47.7° vs. 38.8°, p < .001) and ARC (37.2% vs. 29.7%, p < .001) were significantly greater in the EC (+) group. Multivariate logistic regression analysis revealed that RPV bifurcation angle (odds ratio [OR]: 1.994, p = .002) and ARC (OR: 3.490, p = .013) were independent predictors of EC. In nine patients with EC undergoing carina region mapping, the unipolar potential voltage was correlated with conduction delay in RPV with EC ( R = −0.401, p < .001). Conclusion Anatomical features suggesting a wider RPV carina region could predict the presence of EC, and potential with high voltage could be helpful for detecting EC connection sites.
No takes yet. Share an insight, caveat, or question.
Nehashi et al. (2023) conducted a cohort in Drug-refractory atrial fibrillation (n=251). Higher area occupation ratio of the carina region to the RPV antrum (ARC) and wider RPV bifurcation angle vs. Lower ARC and narrower RPV bifurcation angle was evaluated on Presence of epicardial connection (EC) between the RPV and right atrium (OR 3.490, 95% CI 1.295-9.388, p=0.013). Anatomical features suggesting a wider RPV carina region, specifically the area occupation ratio of the carina region to the RPV antrum, independently predicted the presence of epicardial connections (OR 3.490).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: